Real Betis staged a thrilling comeback to defeat Real Madrid 2-1, with former Los Blancos midfielder Isco delivering the decisive goal.
Madrid, currently second in La Liga, took the lead early when Kylian Mbappe set up Ferland Mendy, who squared the ball for Brahim Diaz to tap into an empty net.
The visitors had opportunities to extend their advantage, but Betis responded in the 34th minute when Johnny Cardoso headed home from Isco’s corner.
Isco, captaining Betis against his former club, completed the turnaround in the 54th minute, converting a penalty after Antonio Rudiger fouled Jesus Rodriguez in the box. Betis nearly added a third when Cucho Hernandez fired wide from an Antony assist.
The Manchester United loanee was available after successfully appealing a red card from last week.
Betis, managed by ex-Madrid and Manchester City boss Manuel Pellegrini, move up to sixth in the La Liga table and fully deserved their victory with 18 shots to Madrid’s nine.
It was the fourth time this season Carlo Ancelotti’s side have lost in La Liga and they remain behind Barcelona on goal difference.
Atletico Madrid could overtake them with a win against Athletic Bilbao later on Saturday (20:00 GMT).
Isco scored 53 goals in 353 games for Real Madrid, winning the Champions League five times and La Liga three times in nine years at the club.
The 32-year-old former Spain attacking midfielder joined Betis in 2023 after a short spell at neighbours Sevilla.
As well as assisting one goal and scoring the other, he ran the show with 97 touches, only behind former team-mate Luka Modric.
He picked up a late yellow card for time wasting.
This was his sixth goal in 15 games this season – with four of them coming in the past month.